| Manchester United | 0-2 | Paris Saint Germain | Old Trafford | 12 Feb | h. 21:00 |
| Roma | 2-1 |  Porto | Stadio Olimpico | 12 Feb | h. 21:00 |
Ajax  | 1-2 | Real Madrid | Johan Cruijff Arena | 13 Feb | h. 21:00 |
Tottenham  | 3-0 |  Borussia Dortmund | Wembley Stadium | 13 Feb | h. 21:00 |
Liverpool  | 0-0 |  Bayern Monaco | Anfield Road | 19 Feb | h. 21:00 |
| Olympique Lione | 0-0 | Barcellona | Parc Olympique Lyonnais | 19 Feb | h. 21:00 |
Atletico Madrid  | 2-0 |  Juventus | Wanda Metropolitano | 20 Feb | h. 21:00 |
| Schalke 04 | 2-3 |  Manchester City | Veltins-Arena | 20 Feb | h. 21:00 |