| Atletico Madrid | 1-0 | Liverpool | Wanda Metropolitano | 18 Feb | h. 21:00 |
| Borussia Dortmund | 2-1 | Paris Saint Germain | Signal Iduna Park | 18 Feb | h. 21:00 |
Atalanta  | 4-1 | Valencia | Giuseppe Meazza | 19 Feb | h. 21:00 |
Tottenham  | 0-1 | Lipsia | Tottenham Hotspur Stadium | 19 Feb | h. 21:00 |
| Chelsea | 0-3 |  Bayern Monaco | Stamford Bridge | 25 Feb | h. 21:00 |
Napoli  | 1-1 | Barcellona | Diego Armando Maradona | 25 Feb | h. 21:00 |
| Olympique Lione | 1-0 |  Juventus | Parc Olympique Lyonnais | 26 Feb | h. 21:00 |
| Real Madrid | 1-2 |  Manchester City | Santiago Bernabeu | 26 Feb | h. 21:00 |