Milan  | 1-0 |  Tottenham Hotspur | Giuseppe Meazza | 14 Feb | h. 21:00 |
Paris Saint Germain  | 0-1 |  Bayern Monaco | Parco dei Principi | 14 Feb | h. 21:00 |
| Borussia Dortmund | 1-0 | Chelsea | Signal Iduna Park | 15 Feb | h. 21:00 |
Club Bruges  | 0-2 | Benfica | Jan Breydel Stadion | 15 Feb | h. 21:00 |
| Eintracht Francoforte | 0-2 | Napoli | Deutsche Bank Park | 21 Feb | h. 21:00 |
Liverpool  | 2-5 | Real Madrid | Anfield Road | 21 Feb | h. 21:00 |
| Inter | 1-0 | Porto | Giuseppe Meazza | 22 Feb | h. 21:00 |
RB Lipsia  | 1-1 | Manchester City | Red Bull Arena | 22 Feb | h. 21:00 |