| Benfica | 5-1 |  Club Bruges | Estadio da Luz | 7 Mar | h. 21:00 |
| Chelsea | 2-0 | Borussia Dortmund | Stamford Bridge | 7 Mar | h. 21:00 |
Bayern Monaco  | 2-0 |  Paris Saint Germain | Allianz Arena | 8 Mar | h. 21:00 |
Tottenham Hotspur  | 0-0 |  Milan | Tottenham Hotspur Stadium | 8 Mar | h. 21:00 |
| Manchester City | 7-0 |  RB Lipsia | City of Manchester Stadium | 14 Mar | h. 21:00 |
| Porto | 0-0 | Inter | Estadio do Dragao | 14 Mar | h. 21:00 |
| Napoli | 3-0 | Eintracht Francoforte | Diego Armando Maradona | 15 Mar | h. 21:00 |
| Real Madrid | 1-0 |  Liverpool | Santiago Bernabeu | 15 Mar | h. 21:00 |