Bayern Monaco  | 3-0 | Lazio | Allianz Arena | 5 Mar | h. 21:00 |
| Real Sociedad | 1-2 |  Paris Saint Germain | Reale Arena | 5 Mar | h. 21:00 |
| Manchester City | 3-1 |  FC Copenhagen | City of Manchester Stadium | 6 Mar | h. 21:00 |
| Real Madrid | 1-1 |  RB Lipsia | Santiago Bernabeu | 6 Mar | h. 21:00 |
| Arsenal | 4-2 (d.c.r) | Porto | Emirates Stadium | 12 Mar | h. 21:00 |
Barcellona  | 3-1 |  Napoli | Camp Nou | 12 Mar | h. 21:00 |
Atletico Madrid  | 3-2 (d.c.r) |  Inter | Wanda Metropolitano | 13 Mar | h. 21:00 |
| Borussia Dortmund | 2-0 | PSV Eindhoven | Westfalenstadion | 13 Mar | h. 21:00 |