Ajax  | 2-1 |  Lille | Johan Cruijff Arena | 25 Feb | h. 18:55 |
| Arsenal | 3-2 |  Benfica | Georgios Karaiskakis | 25 Feb | h. 18:55 |
| Glasgow Rangers | 5-2 |  Anversa | Ibrox Stadium | 25 Feb | h. 18:55 |
| Hoffenheim | 0-2 |  Molde | Wirsol Rhein-Neckar-Arena | 25 Feb | h. 18:55 |
| Napoli | 2-1 |  Granada | Diego Armando Maradona | 25 Feb | h. 18:55 |
Shakhtar Donetsk  | 1-0 |  Maccabi Tel Aviv | Arena Leopoli | 25 Feb | h. 18:55 |
| Tottenham | 4-0 |  Wolfsberger | Tottenham Hotspur Stadium | 25 Feb | h. 18:55 |
| Villarreal | 2-1 |  Salisburgo | Estadio de la Ceramica | 25 Feb | h. 18:55 |
| Bayer Leverkusen | 0-2 |  Young Boys | BayArena | 25 Feb | h. 21:00 |
Club Bruges  | 0-1 |  Dinamo Kiev | Jan Breydel Stadion | 25 Feb | h. 21:00 |
| Dinamo Zagabria | 1-0 |  Krasnodar | Stadion Maksimir | 25 Feb | h. 21:00 |
| Leicester | 0-2 |  Slavia Praga | King Power Stadium | 25 Feb | h. 21:00 |
Manchester United  | 0-0 |  Real Sociedad | Old Trafford | 25 Feb | h. 21:00 |
| Milan | 1-1 |  Stella Rossa | Giuseppe Meazza | 25 Feb | h. 21:00 |
| PSV Eindhoven | 2-1 |  Olympiakos | Philips Stadion | 25 Feb | h. 21:00 |
| Roma | 3-1 |  Sporting Braga | Stadio Olimpico | 25 Feb | h. 21:00 |