| Brentford | 3-2 | Bournemouth | Griffin Park | 9 Nov | h.16:00 | |
| Crystal Palace | 0-2 | Fulham | Selhurst Park | 9 Nov | h.16:00 | |
| West Ham United | 0-0 | Everton | The Stadium | 9 Nov | h.16:00 | |
| Wolverhampton Wanderers | 2-0 | Southampton | Molineux Stadium | 9 Nov | h.16:00 | |
| Brighton | 2-1 | Manchester City | The Amex Stadium | 9 Nov | h.18:30 | |
| Liverpool | 2-0 | Aston Villa | Anfield Road | 9 Nov | h.21:00 | |
| Manchester United | 3-0 | Leicester City | Old Trafford | 10 Nov | h.15:00 | |
| Nottingham Forest | 1-3 | Newcastle United | City Ground | 10 Nov | h.15:00 | |
| Tottenham Hotspur | 1-2 | Ipswich Town | Tottenham Hotspur Stadium | 10 Nov | h.15:00 | |
| Chelsea | 1-1 | Arsenal | Stamford Bridge | 10 Nov | h.17:30 |